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      Translational Research Initiative for Hearing Grant

      Our Translational Research Initiative for Hearing (TRIH) Grant helps move research closer to patients. The grant is international. We fund applied research projects at research institutes and small to medium enterprises (SMEs) across the world.

      The TRIH Grant supports:

      • research with strong commercial potential, likely to attract follow-on funding at the conclusion of the grant.
      • studies that will facilitate and enable the progression of promising basic research towards testing in clinical trials.

      The TRIH Grant does not support basic research into the causes and underpinning biology of hearing loss and tinnitus or the development of devices or software.

      TRIH Grant 2018

      • Duration: up to three years
      • Eligibility: applicants may be from any country and may be from academic institutions and small/medium enterprises
      • Value*: up to £100,000 per year
      • Deadlines:
        • Expression of interest: 20 November 2017 (5pm GMT)
        • Full application (by invitation only): 19 January 2018 (5pm GMT) 
        • Funding decisions: July 2018

      * Please note that we are a charity. We cannot fund any indirect costs – or the salaries of permanent employees.

      Application procedure

      First, an expression of interest must be submitted using the form below. This gives us enough information about the proposed project to understand how well it aligns with the requirements and eligibility of the TRIH scheme.

      Applicants whose proposals meet the criteria of the scheme are then invited to submit a full application.

      Stages of the application procedure

      The stages of the TRIH Grant application process

      1. Expression of interest

      Expressions of interest are open entry. 

      2. Assessment

      Additional information may be requested in order to determine whether an application meets the scheme's criteria. 

      3. Full application

      Full applications are made by invitation only, if your expression of interest is successful.

      4. External assessment

      All full applications are sent to two or three external referees. These referees rate the scientific value, feasibility and translational potential of each project. Applicants can then respond to the reviewer's feedback if they wish.

      5. TRIH Funding Review Panel assessment

      The panel considers the full applications and expert reviews, assessing scientific approach and commercial and/or translational potential. 

      6. Funding 

      Projects are ranked competitively and funding is awarded to the top-rated projects. 

      How to apply

      Use the form below to submit your expression of interest.

      Applicants whose proposals meet the scheme's criteria will be invited to submit a full application. See the document below for full details.

      Requirements and eligibility

      The scope of the Translational Research Initiative for Hearing call varies from year to year. This year, applications will be accepted in the following areas:

      Small molecule, gene or cell-based approaches for the treatment of hearing loss or tinnitus

      This can include:

      • Studies which will enable lead optimisation and/or candidate selection.
      • Pharmacokinetic/Pharmacodynamic (PKPD) studies.
      • Safety/toxicology studies.
      • Drug repositioning/repurposing (applications must contain preliminary data supporting the proposed approach).

      Research that addresses at least one of the 'TRIH Challenge' topics

      These topics are listed below. 

      • Validation of therapeutic targets for the treatment of hearing loss or tinnitus (applications must contain preliminary data supporting the proposed approach).
      • Studies to strengthen confidence that a target or therapeutic approach will be applicable to human hearing loss or tinnitus.
      • Preclinical model validation, for example, studies to increase the understanding of in-vivo or in-vitro model relevance to human hearing loss or tinnitus.
      • Identification/validation of methods or outcomes that could be used for one or more of the following:
        • patient selection/stratification for clinical trials
        • robust measurement of treatment responses in clinical trials.

      Areas in which applications will NOT be accepted

      This year, applications will not be accepted in the following areas:

      • Basic research into the causes and underpinning biology of hearing loss and tinnitus.
      • The development of devices or software.
      • The optimisation of current clinical protocols.
      • Health service studies.

      Selection procedure

      All applications are sent to two/three external referees in the field who are asked to rate the scientific value, feasibility, and translational potential of the project. The applications and associated peer reviews are then assessed and rated by members of our TRIH funding review panel. The top-rated applications are then put forward for funding.

      We decide who to fund based on scientific merit, feasibility, the TRIH Grant eligibility criteria above, and relevance to our Biomedical Research Strategy. Everyone involved in the review process of any grant application is asked to abide by our Code of Conduct and to sign a reviewer agreement with confidentiality clauses. 

      Applicants are notified of the outcome as soon as possible following the final decision. Feedback is provided to all applicants.

      TRIH Funding Review Panel

      • Dr Rick Cousins (GSK)
      • Dr Paul England (IOTA Pharmaceuticals Ltd)
      • Dr Paul Fletcher (Leigh-Abbot Consulting Ltd)
      • Dr Jonathan Gale (University College London)
      • Dr Fiona Marston (Sapere Systems Ltd)
      • Professor Gerard O’Donoghue (Nottingham Hearing Biomedical Research Unit)
      • Professor Karen Steel (King's College London)
      • Dr Sylvie Cosnier-Pucheu (CILcare)
      • Dr Judith Langfield (Patient representative) 

      Project management and reporting

      Successful TRIH grants require annual scientific and financial reporting. This ensures that the milestones are met and the project is successfully completed.

      Europe PubMed Central (Europe PMC) and open access publications

      Action on Hearing Loss is a member of the Europe PMC Funders' Group. We support open access publications and require Action on Hearing Loss grant holders to make their publications open access.

      Read our open access publication policy for more information and visit the Europe PMC website.

      For more information

      Please get in touch if you would like more information about the TRIH grant.

      Email: trih@hearingloss.org.uk
      Telephone: +44 (0)20 32276020

      Current TRIH projects

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